Colistimethate Sodium injection (Xylistin 4.5 Miu INJ)

Colistimethate Sodium injection (Xylistin 4.5 Miu INJ) About

USES OF XYLISTIN 4.5MIU

• Treats serious bacterial infections

HOW XYLISTIN 4.5MIU WORKS

XYLISTIN 4.5MIU kills the susceptible bacteria that causes infection. It acts by disrupting the composition (lipids and protein) of the bacterial cell membrane and enters the bacterial cell. This causes the contents of the bacterial cell to leak out which subsequently leads to bacterial killing. It may also inactivate the effects of toxins produced by the harmful bacteri

DIRECTIONS FOR USE

XYLISTIN 4.5MIU will be given to you only by a doctor or nurse into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and severity of infection

SIDE EFFECTS OF XYLISTIN 4.5MIU COMMON

• Stomach upset
• Tingling sensation in the extremities or in the tongue
• Paraesthesia (loss of sensation)
• Dizziness
• Skin rash, itching
• Fever
• Breathing difficulty
• Increased kidney enzymes

RARE

Contact your doctor immediately if you experience any of the following side effects after receiving XYLISTIN 4.5MIU:

• Severe allergic reaction (such as skin rash, itching, sudden swelling of the face, throat or lips leading to wheezing or breathing difficulties)
• Inability to breathe because of paralysis of the chest muscles, sense of tingling or numbness especially around the face, feeling dizzy, loss of balance, rapid changes in blood pressure or blood flow causing flushing or fainting, problems in speech, problems with vision, confusion, and mental problems (including loss of sense of reality)
• Kidney damage with symptoms such as little or no urination, painful or difficult urination, swelling in your feet or ankles, feeling tired or short of breath

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely if you feel dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

Skin rash:

Avoid taking hot showers, as it may further irritate your skin. Use protective clothes while going outdoors. Avoid scratching the affected area of the skin. Regularly moisturize your skin. Consult your doctor if your condition worsens.

WARNING & PRECAUTIONS

PREGNANCY

XYLISTIN 4.5MIU should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before receiving it.

BREASTFEEDING

XYLISTIN 4.5MIU should be used with caution in breast-feeding women. Therefore, consult your doctor before receiving it.

DRIVING AND USING MACHINES

Do not drive or operate any heavy tools or machines if you experience dizziness, confusion or blurred vision after receiving XYLISTIN 4.5MIU.

ALCOHOL

Avoid consumption of alcohol while receiving XYLISTIN 4.5MIU.

KIDNEY

XYLISTIN 4.5MIU should be used with caution in patients suffering from kidney problems. Therefore, consult your doctor before receiving it.

LIVER

XYLISTIN 4.5MIU should be used with caution in patients suffering from liver problems. Therefore, consult your doctor before receiving it.

ALLERGY

Inform your doctor before receiving XYLISTIN 4.5MIU if you are allergic to colistin.

OTHERS

Before receiving XYLISTIN 4.5MIU inform your doctor if you:

• Have myasthenia gravis (weak muscles)
• Have porphyria (an inherited blood disorder)

Use in pediatrics:

XYLISTIN 4.5MIU should be used with caution in children and adolescents (aged below 18 years). Therefore, consult your doctor before receiving it.

Use in geriatrics:

XYLISTIN 4.5MIU should be used with caution in elderly patients. Therefore, consult your doctor before receiving i

INTERACTIONS

A. Drug-Drug Interaction:

Before receiving XYLISTIN 4.5MIU, inform your doctor if you are taking any of the following medicines such as:

• Other antibiotics such as aminoglycosides (Ex. netilmicin, gentamicin, amikacin, and tobramycin), cephalosporins (Ex. cefixime, ceftriazone), macrolides (Ex. azithromycin, clarithromycin or erythromycin) or fluoroquinolones (ofloxacin, norfloxacin and ciprofloxacin)
• Muscle relaxant medications (used for relaxing muscles before surgery) Ex. atracurium, vecuronium

Effective Management of Resistant Infections

Xylistin offers reliable antibacterial action against stubborn Gram-negative infections, particularly those that are resistant to standard antibiotics. Its unique formulation delivers targeted results for patients at risk, making it an invaluable resource for hospitals handling critical cases. The inclusion of sterile water and a clearly defined reconstitution process ensure high safety and purity standards.


Comprehensive Hospital and Clinical Use

Designed specifically for clinical and hospital environments, Xylistin suits the rigorous demands of infection control in high-risk settings. The medicine is imported and available via authorized distributors across India, and is exclusively dispensed on prescription to safeguard optimal therapeutic outcomes for both adult and pediatric patients.